In "Antipasto", Dr. Bedelia Du Maurier (Gillian Anderson) is seen drawing a two-tone SIG-Sauer P226 on Hannibal when he turns up at her house after the events of the Season 2 finale. Will Graham (Hugh Dancy) is seen with his FBI issue P226 a few times in the season, firstly in "Primavera" during a flashback, and secondly in "The Wrath of The Lamb" during a confrontation with Lecter and Dolarhyde.
In "Primavera", Inspector Rinaldo Pazzi (Fortunato Cerlino) carries a Beretta 92FS as his sidearm, drawing it when he follows Will Graham (Hugh Dancy) into the catacombs of a cathedral in Palermo. In "Digestivo", several corrupt Florentine detectives working for the Vergers are seen armed with Berettas when they apprehend Hannibal and Will. An FBI agent at the end of the episode is also briefly seen armed with a Beretta.
Francis Dolarhyde (Richard Armitage) carries a suppressed Beretta 92FS Inox as his sidearm throughout the season. He uses it notably in "...And the Beast from the Sea" during his attack on the Graham household and "The Wrath of The Lamb" whilst ambushing a police convoy transporting Dr. Hannibal Lecter (Mads Mikkelsen). In "The Great Red Dragon", Will Graham (Hugh Dancy) uses the same gun during his mental recreation how Dolarhyde murdered the Leeds family.
During a flashback in "Aperitvio", Miriam Lass (Anna Chlumsky) is seen using Jack Crawford's Glock 17 shoot and injure Dr. Frederick Chilton. In "Dolce", Jack Crawford (Laurence Fishburne) is also seen briefly using a Glock 17 during his pursuit of Hannibal in Florence. In "And the Woman Clothed in Sun", a security guard at the Brooklyn Museum is seen with a holstered Glock 17. In "The Wrath of The Lamb", Baltimore Police Department officers killed by Francis Dolarhyde (Richard Armitage) are also seen with holstered Glocks.
In "Digestivo", Mason Verger (Joe Anderson) briefly arms himself with a Walther PPK with light wooden grips. He later uses it to try and shoot Dr. Alana Bloom (Caroline Dhavernas), but is tackled by his sister before being able to do so.
In "Secondo", Chiyoh (Tao Okamoto) is seen hunting with a double barrel shotgun on the Lecter Estate in Lithuania. She later uses it to confront Will Graham (Hugh Dancy) when she finds him trespassing.
In "The Wrath of The Lamb", Francis Dolarhyde (Richard Armitage) is seen using a stainless pistol gripped Remington 870 Police Magnum to threaten Reba McClabe (Rutina Wesley). In the same episode, an FBI agent guarding Dr. Hannibal Lecter (Mads Mikkelsen) in transit is also armed with a full length version of the shotgun.
In "Dolce", Chiyoh (Tao Okamoto) uses a suppressed Remington 700 to injure Will Graham (Hugh Dancy) to prevent him from stabbing Hannibal. She is later seen using the same rifle in "Digestivo", most notably to save Jack Crawford (Laurence Fishburne) from being killed by corrupt Italian detectives working for the Vergers.
In "Digestivo", a henchman working for Mason Verger (Joe Anderson) is briefly seen armed with a Heckler & Koch UMP as Hannibal and Will are delivered to the Verger Estate. In "The Wrath of The Lamb", an FBI agent escorting Dr. Alana Bloom (Caroline Dhavernas) and her family to safety is also briefly seen armed with a UMP.
One of Mason Verger's henchmen guarding Hannibal (Mads Mikkelsen) is armed with an X2 CO2 Dart Pistol, which is picked up and used by Dr. Alana Bloom (Caroline Dhavernas) to subdue him.
