The Beretta 92FS is seen several time during this film. First by Mercury (Arly Jover) in the nightclub at the beginning of the film, by a hospital security guard, by Officer Krieger (Kevin Patrick Walls) to threaten Dr. Karen Jenson (N'Bushe Wright), and finally seen in a vampires hands later in the film.
When Blade (Wesley Snipes) goes to the hospital to finish off Quinn (Donal Logue), several hospital security guards fire at him, one having a Colt Python.
Blade (Wesley Snipes) hands a Glock 26 loaded with silver hollow point bullets to Karen (N'Bushe Wright) to defend herself. She also uses this gun at another point in the film to shoot at one of the familars Deacon Frost (Stephen Dorff) sends just before she and Whistler (Kris Kristofferson) are captured.
Blade's (Wesley Snipes) machine pistol is a modified MAC-11.
Blade used a modified MAC-11 as the firing portion of the hero gun, with a cast MAC-10 shell as the forward portion of the hero gun.
One of the familiars in the library is seen armed with a Sterling L2A3 submachine gun. Another familiar is seen firing a Sterling L2A3 at Blade, Whistler and Karen Jenson when they made their escape from the vampire library.
When Whistler (Kris Kristofferson) rescues Blade (Wesley Snipes), and Karen (N'Bushe Wright) in the vampire library, he is seen using an H&K MP5SD3 to mow down several familiars. The muzzle flash seen here is impossibly large and bright for a suppressed weapon; it's the result of using a mock suppressor can, combined with full-flash motion picture blanks.
When Blade (Wesley Snipes) escapes the hospital with Karen Jenson (N'Bushe Wright), a SWAT officer fires at him with a Heckler & Koch HK33, from a window, but misses. Several vampires are also seen wielding these weapons.
The shotgun that Blade (Wesley Snipes) uses in the film is a Benelli M3 Super 90 with a pistol grip, modified to fire silver stakes, as well as normal ammunition.
Just before Whistler (Kris Kristofferson) and Karen (N'Bushe Wright) are capture by Frost's (Stephen Dorff) men. Whistler can be seen using a Mossberg 590 Mariner to fire at several vampires and familiars running around the lair.
Several vampires can be seen with Mossberg 590s towards the end of the film, theirs are equipped with pistol grips, one of which Karen commandeers and uses.
