Some of the buffalo hunters on the train carry Winchester Model 1873 rifles. Marvin Throneberry, a U.S. Marshal tracking Blake, also carries a Model '73.
Sharps 1874 Cavalry Carbine
Several characters, including the buffalo hunters and fur trader Benmont Hench (Jared Harris) carry Sharps 1874 Carbine rifles. Salvatore "Sally" Jenko (Iggy Pop) briefly picks up Hench's Sharps.
Colt 1860 Army
The man being "serviced" in the alley (Gibby Haines) when Blake first arrives in Machine aims a Colt 1860 Army at Blake. Johnny "the Kid" Pickett (Eugene Byrd) also carries two Colt Army revolvers.
double-barreled shotgun
John Dickinson (Robert Mitchum) carries a double-barreled shotgun with exposed hammers while inside his office. Behind his desk is a portrait of him standing with his shotgun as well. "Big George" Drakoulious (Billy Bob Thornton) also has a double-barreled shotgun, which Nobody (Gary Farmer) takes after slashing his neck. Nobody then tosses the shotgun to William Blake (Johnny Depp).
Single Action Army
William Blake (Johnny Depp) discovers a blued Single Action Army Quickdraw model under Thel Russell's (Mili Avital) pillow, which she promptly places under her pillow. After using the SAA to shoot Charlie, Blake takes it and carries it through the rest of the film. Bounty hunter Cole Wilson (Lance Henriksen) carries a nickel Quickdraw SAA.
Smith & Wesson Schofield
Charlie Dickinson (Gabriel Byrne) shoots Thel Russell with a blued Smith & Wesson Schofield. The bullet apparently passes through Thel, killing her, and enters Blake's chest next to his heart.
U.S. Marshal Lee Hazelwood carries a Winchester 1866 "Yellow Boy". Blake (Johnny Depp) later takes this rifle and, after killing another man with it, offers it to Nobody (Gary Farmer), who fires it in the final scene.
Colt 1849 Pocket
The trading post missionary (Alfred Molina) attempts to draw a Colt 1849 Pocket but Blake knocks it away from him and shoots him with his SAA. Blake then takes the Colt 1849 Pocket and holds it in the canoe as he and Nobody float away.